E102 Vet Med Building
University of Missouri
Columbia, MO 65211
PhD—University of Iowa
Room 30 VSB
Pam Thorne—Research Assistant &
Ann Melloh—Research Specialist
David Harah—Research Specialist
Robert Johnson—Research Specialist
Kevin Eklund—Graduate Student
Jessica Taylor—Graduate Student
Ryan Jankord—Graduate Student
Research Interests: Exercise
Vascular Cell Biology
Dr. Laughlin focuses his research on cardiovascular
effects of exercise. The primary goal is
to understand the effects of exercise training
on the coronary circulation and skeletal
muscle vascular beds. Exercise training
produces increases in the capacity of myocardial
and skeletal muscle vascular beds to transport
oxygen and other nutrients.
The training-induced changes in vascular
transport capacity are associated with growth
of new capillaries, enlargement of arteries
and veins, and alterations in factors that
control blood flow in the heart and skeletal
muscle. The lab is currently investigating
the mechanisms responsible for these changes.
Studies are conducted with: isolated hearts,
isolated muscle tissue, single blood vessels
and in conscious, chronically instrumented
animals during exercise. To allow examination
of the relationship among vascular adaptations
and the response of the myocytes to training-induced
increases in the functional demands of the
muscles, the effects of training on biochemical
and histological characteristics of the
muscles are also measured.
Dr. Laughlin’s research, which is
supported by the PPG, evaluates the role
of exercise training-induced changes in
endothelial phenotype in the protective
effects of exercise on atherosclerotic coronary
Johnson, L. R., J. W. E. Rush, J. R. Turk,
E. M. Price, and M. H. Laughlin. Short-term
exercise training increases Ach-induced
relaxation and eNOS protein in porcine pulmonary
arteries. J. Appl. Physiol., 90: 1102-1110,
Schrage, W. G. CR Woodman, and Laughlin
MH: Mechanisms of flow and ACh-induced dilation
in rat soleus arterioles are altered by
hindlimb unweighting. J. Appl. Physiol.,
Aaker, A. and Laughlin M. H. Diaphragm arterioles
are less responsive to a1-adrenergic constriction
than gastrocnemius arterioles. J. Appl.
Physiol., 92:1808-1816, 2002.
Woodman, C. R., J. R. Turk, James W. E.
Rush, and Laughlin M. H. Exercise attenuates
the effects of hypercholesterolemia on endothelium-dependent
relaxation in coronary arteries from adult
female pigs. J. Appl. Physiol., 96:1105-1113,
Thompson, M. A., K. K. Henderson, C. R.
Woodman, J. R. Turk, James W. E. Rush, and
M. H. Laughlin. Exercise Preserves Endothelium-Dependent
Relaxation in Coronary Arteries of Hypercholesterolemic
Male Pigs. J. Appl. Physiol., 96:1114-1126,
Laughlin M.H. Joseph B. Wolfe Memorial lecture.
Physical Activity in Prevention and Treatment
of Coronary Disease: The Battle Line is
in Exercise Vascular Cell Biology. Med.
& Sci. In Sports & Exercise. 36:352-362,