Email:
SchadtJ@missouri.edu
Research Interests: Neurohumoral
control of the circulation
Teaching: Neurophysiology
Dr. Schadt's research interests are concerned
with the role of endogenous opioid peptides
and other endogenous neurohumoral substances
in cardiovascular control.
His work has concentrated on the role of
these compounds during hemorrhage. These
experiments have documented the existence
of a potent blood pressure lowering system
that limits maintenance of blood pressure
during blood loss.
His current studies are directed at three
aspects of cardiovascular control: 1) the
stimuli which activate the depressor system
during blood loss; 2) interactions of various
neurohumoral systems involved in cardiovascular
control; and 3) interactions of environmental
stimuli with cardiovascular control mechanisms.
Selected Publications:
Schadt JC, and Ludbrook J. Hemodynamic and
neurohumoral responses to acute hypovolemia
in conscious animals. Am. J. Physiol. (Heart
Circ. Physiol.), 260:H305-H318, 1991.
Jang W, Schadt JC, and Gaddis RR. Peripheral
opioidergic mechanisms do not mediate naloxone's
pressor effect in the conscious rabbit.
Circ. Shock, 39:121-127, 1993.
Schadt JC. Experimental studies--animals.
In: Blood loss and hypovolaemic shock, edited
by N. H. Secher, J. Pawelczyk, and J. Ludbrook.
Kent, England: Edward Arnold, 1994.
Koch MA, Hasser EM, and Schadt JC. Influence
of nitric oxide on the hemodynamic response
to hemorrhage in the conscious rabbit. Am.
J. Physiol. 268 (Regulatory Integrative
Comp. Physiol. 37):R171-R182, 1995.
James
C. Schadt, PhD