Research Interests: Aging
and development of Collateral Circulation.
Dr. Yang is using a rat model with peripheral
arterial insufficiency (a cardiovascular
disease commonly seen in the elderly) to
study the mechanisms of expanding collateral
circulation. The effect of aging process
on arteriogenesis (growing of new arteries)
and angiogenesis (growing of new capillary)
in response to obstruction of a conduit
artery are studied. The molecular basis
and functional responses of expansion of
collateral circulation, induced by physical
activity and administration of angiogenic
growth factors are assessed, the outcome
from this research will provide important
information to treat the patients with peripheral
arterial insufficiency.
Selected Publications:
Srivastava, S., R.L Terjung and H.T. YANG.
Basic fibroblast growth factor increases
collateral blood flow in spontaneously hypertensive
rats. Am. J. Physiol. (Heart Circ. 285)H1190-H1197,
2003.
Prior, B.M., P.G. Lloyd, J. Ren, Z. Li,
H.T. Yang, H.M. Laughlin, and R.L. Terjung.
Ateriogenesis:Role of Nitric Oxide. Endothelium
10:207-216, 2003.
Prior, B.M., H.T. Yang, and R. L. Terjung.
What makes vessels grow with exercise training?
J. Appl. Physiol. 97:1119-1128, 2004.
Lloyd, P.G., P.M. Prior, H. Li, YANG, H.T.,
and R.L Terjung. VEGF receptor antagonism
blocks arteriogenesis, but only partially
inhibits angiogenesis, in skeletal muscle
of exercise trained rats. Am. J. Physiol.
(Heart Circ. 2xx) in print, 2004.
Prior, B.M., P.G. Lloyd, J. Ren, H. Li,
H.T. Yang, H.M. Laughlin, and R.L. Terjung.
Time-course of changes in collateral blood
flow, and isolated vessel size and gene
expression following femoral artery occlusion
in the rat. Am. J. Physiol. (Heart Circ.
287)H2434-H2447, 2004.
Steve
H.T. Yang, PhD